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Resident Research »  Leadership »  Research Committee Members »  Julius M. Guccione, Jr., Ph.D.

Julius M. Guccione, Jr., Ph.D.

Professor of Surgery in Residence
Division of Adult Cardiothoracic Surgery
Co-Director, Cardiac Biomechanics Lab
Affiliate, UC Berkeley & UCSF Graduate Program in Bioengineering

Contact Information

Academic Office

Department of Surgery
1657 Scott St., Brunn Bldg., Room 219
San Francisco, CA 94143
415.750.2181 (Fax)
415.680.6285 (Cell/Mobile)
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  • Tulane University B.S. Biomedical Engineering, 1985
  • UCSD, M.S. Engineering Sciences (Bioengineering), 1987
  • UCSD, Ph.D. Engineering Sciences (Bioengineering), 1990
  • Postdoctoral Fellow, Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 1990-1993
  • Member, UCB/UCSF Graduate Bioengineering Program

Julius M. Guccione, Ph.D. is Professor in Residence in the UCSF Department of Surgery, specializing in realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. He is the sole PI on one active R01 (HL077921: Virtual Tools for Cardiac Ventricular Remodeling Surgery). He is the contact PI on another active R01 (HL118627: Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure). Recently, he was notified by the NHLBI that he soon will become the contact PI on a new U01 (HL119578-01A1: Multi-Scale Laws of Myocardial Growth and Remodeling).

Dr. Guccione graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

  • AIMBE Fellow, American Institute for Medical and Biological Engineering (AIMBE) College of Fellows, 2019
  • Richard Skalak Best Paper Award of the ASME Bioengineering Division, 1999
  • Individual National Research Service Award of the NIH, 1991-1993
  • Institutional National Research Service Award, Johns Hopkins University, Baltimore, MD, 1990-1991
  • Institutional National Research Service Award, University of California, San Diego, CA, 1985-1990

Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. Recently, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

See also: The 3D Living Heart Project Overview

From a total of 118 publications
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